![]() We found that clones derived after the accumulation of 90–200 progenitors in the cerebral cortex tended to respect the midline axis, well before the anterior-posterior or ventral-dorsal axes, which represents a secondary hierarchy following the overall patterning of fore- and hindbrain domains. We identified 259 bona fide mosaic variants from the index case, then deconvolved distinct geographic, cell type, and clade organizations across the brain and other organs. ![]() We combined sampling of 25 distinct anatomic locations with deep whole genome sequencing in a neurotypical deceased individual and confirmed results with five samples collected from each of three additional donors. We analyzed neocortical clones in a postmortem human brain through a comprehensive assessment of brain somatic mosaicism, acting as neutral lineage recorders 1, 2. Here we sought to reconstruct processes that occur during early development through the sampling of adult human tissues. ![]() ![]() The structure of the human neocortex underlies species-specific traits and reflects intricate developmental programs.
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